More importantly, we noted that aged Atg16l1/Xbp1/Rnaseh2bΔIEC mice spontaneously presented with nearly complete penetrance of small intestinal tumors (95.0%), when compared to Xbp1/Rnaseh2bΔIEC mice (61.7%) (Fig. 6A). Here, XBP1 is linked to small intestine neoplasm.