ATG16L1 and adenocarcinoma: In fact, mice with functional autophagy even displayed a tendency to develop more dedifferentiated carcinomas, as we found more high-grade adenocarcinomas in Xbp1/Rnaseh2bΔIEC mice compared to Atg16l1/Xbp1/Rnaseh2bΔIEC mice (Fig. 6D, E).