Comparing RNA seq data of polatuzumab vedotin resistant (RCK‐8 and SU‐DHL‐2) and sensitive cell lines (all other DLBCL cell lines tested) using the limma pipeline revealed Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) as the second most upregulated gene in resistant cells (log2‐fold change = 11.06; adjusted p < 0.001) (Table S1). This evidence concerns the gene ALDH1L1 and diffuse large B-cell lymphoma.