BCR and Miyoshi myopathy: In this study, BM samples from healthy volunteers, as well as patients with MGUS, SMM and newly diagnosed MM were profiled using multi-modal single-cell -omics techniques, including single-cell RNA sequencing (scRNA-seq), cellular indexing of transcriptomes and epitopes by antibody derived tag sequencing (ADT-seq) and B-cell receptor sequencing (BCR-seq), to investigate the status of the BM microenvironment, dysregulation of the immune system, and interaction between BM immune cell populations and tumoral plasma cells to better understand progression to MM.