This subpopulation was present in higher proportions in MM compared to HV (p < 0.001), MGUS (p < 0.005), and SMM (p < 0.5) and did not express exhaustion markers (PD-1-, TIM-3-, LAG-3-, TIGIT-) indicating the presence of a functional, activated NK cell subset in the BM. This evidence concerns the gene TIGIT and Miyoshi myopathy.