During our research on small-molecule modulatorsof epigenetictargets, we identified and described several chemically distinct inhibitorsand activators of human sirtuins with potential anticancer activity.−, , , , , , , , , , , , , , , , , , , ,  Among these, benzodeazaoxaflavins (BDFs) emerged as some of themost potent, inhibiting hSirt1/2 at low micromolar concentrationsand reducing proliferation in various cancer cell lines, includingcolon carcinoma and glioblastoma cancer stem cells., The gene discussed is SIRT1; the disease is cancer.