KCNH2 and tuberculosis: Thenewly synthesized pyrazolopyridine scaffold in TB47 retains a similar3D conformation and electronic properties to the original structure,maintaining the critical H-bond with Glu314 residue of QcrB., TB47 demonstrated sustained efficacy against DR-TB strains and exhibitedcomparable activity against Mtb as Q203 (MIC90 H37Rv = 11.1 nM after 7 days), low cardiotoxicity(hERG IC50 > 30 μM), a 10-fold lower clogP value compared to Q203 and good oral bioavailability inmice models.,