KCNH2 and tuberculosis: Nevertheless,its favorable in vivo PK profile, low hERG channelaffinity (IC50 > 30 μM), and minimal inhibitionofCYP enzymes (IC50 values > 45 μM across a paneloffive isoforms) allowed this derivative to advance to preclinical development,aiming to evaluate the potential replacement of LNZ with OTB-658 inanti-TB regimens.