On the submucosa (Fig. 13C) of the control, the expression of α-SMA was detected only in the wall of the blood vessels; meanwhile, in the colitis (Fig. 13b1, b2), clove (Fig. 13c1, c2), and PCL@CS + ALG (Fig. 13d1, d2) group, the expression of it was detected in the interstitial myofibroblast and their immune density expression was significantly increased (p < 0.05) compared to the control group. Here, ACTA1 is linked to colitis.