TLR7 and infection: Provocatively, the authors also showed reductions in viral DNA in peripheral blood mononuclear cells (PBMC) and gut and lymph node tissues in animals treated with TLR7 agonists, suggestive of clearance of residual infected cells, with two of nine TLR7 agonist-treated animals showing no viral rebound upon cART cessation, indicative of infection remission (31).