By contrast, other published studies that involved TLR7 agonist administration to SIV/SHIV-infected macaques on cART utilized earlier cART initiation, during the acute phase of infection (32, –, 34, 36, –, 39), a longer duration of cART prior to TLR7 agonist treatment (33, –, 35), and/or less sensitive virologic monitoring assays (32, 33, 38). Here, TLR7 is linked to infection.