Through phenome-wide association studies, the most significant associations with each protein were with cardiac dysrhythmias (NT-proBNP), atrial fibrillation and flutter (BNP), chronic renal failure (ACTA2, BAG3, NOTCH1, ACTN4), type-2 diabetes (ACE2, CDKN1A), and congestive heart failure (TNNI3; Figure 4; Table S3; Figures S6 through S20). The gene discussed is NOTCH1; the disease is atrial flutter.