Although the measures are highly correlated (R=0.67), there are important differences in measurable levels: NT-proBNP is measured at a higher concentration, has a higher prognostic value,47 has been shown to have sustained elevation for 12 weeks,48 the predictive capacity of the ratio of NT-proBNP:BNP has been explored previously,49 we show that NT-proBNP was more predictive of heart failure, other cardiovascular diseases, and risk factors and is more influenced by genetic factors (heritability) than BNP. This evidence concerns the gene NPPB and heart failure.