NPPB and cardiovascular disorder: Although the measures are highly correlated (R=0.67), there are important differences in measurable levels: NT-proBNP is measured at a higher concentration, has a higher prognostic value,47 has been shown to have sustained elevation for 12 weeks,48 the predictive capacity of the ratio of NT-proBNP:BNP has been explored previously,49 we show that NT-proBNP was more predictive of heart failure, other cardiovascular diseases, and risk factors and is more influenced by genetic factors (heritability) than BNP.