To detail at cellular level the effect of EPG5 mutations involved in the expanding spectrum of EPG5‐related movement disorders including parkinsonism and distinct from classical VS, we investigated human fibroblasts homozygous for the EPG5 variant c.6861_6862insTTTCCAACAGCAGAGTTC, p.Phe2287_Leu2288insPheProThrAlaGluPhe identified in EPG5‐related parkinsonism (patient 3), as well as two fibroblast cell lines with the recurrent EPG5 Vici syndrome variants p.Gln336Arg and p.Arg1621Gln (patients 1 and 2), respectively. The gene discussed is EPG5; the disease is Parkinson disease.