PRKN and Parkinson disease: As an easily genetically manipulated in vivo model for motor phenotypes and mitochondrial function, we conducted knockdown of epg‐5/EPG5 in a C. elegans model, and observed a hypokinetic phenotype with decreased body bends and lower thrashing similar to knockdown of both other autophagosome–lysosome fusion genes (rab‐7/RAB7A, ccz‐1/CCZ1) and of Parkinson's disease‐associated gene pdr‐1/PRKN (Fig 7A,B), corroborating previous findings in established C. elegans models of Parkinson's disease.26