Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease.<h4>Purpose</h4>To explore if increased levels of OPN and SGHS are associated with hospitalization for kidney failure in patients with acute heart failure (HF).<h4>Methods</h4>OPN was analyzed in 315 hospitalized HF patients using a proximity extension assay. The gene discussed is SPP1; the disease is kidney failure.