RBCK1 and hepatocellular carcinoma: Next, to confirm the oncogenic role of HOIL-1 in vivo, we applied subcutaneous HCC nude mouse models by subcutaneously injecting 5 × 106 Huh7 (transfected with shHOIL-1 or shCtrl) or HCCLM3 (transfected with LV-HOIL-1 or LV-Ctrl) cells.