RBCK1 and hepatocellular carcinoma: We manipulated the expression of HOIL-1 in HCC cells using the lentivirus (Supplementary Fig. 3b–e) and found that HOIL-1 knockdown impaired the proliferative capacity of HCC cells, whereas HOIL-1 overexpression had an opposite effect (Fig. 3a, b and Supplementary Fig. 3f).