In addition, data from the TCGA LIHC dataset indicated that HOIL-1 mRNA levels were upregulated in 58% of HCC cases (29/50; log2(fold change) >1; Fig. 2d) and significantly elevated in the tumor tissues when compared with that in nontumor tissues in the Oncomine and GEO cohorts (Fig. 2e, f). This evidence concerns the gene RBCK1 and neoplasm.