RBCK1 and hepatocellular carcinoma: In addition, data from the TCGA LIHC dataset indicated that HOIL-1 mRNA levels were upregulated in 58% of HCC cases (29/50; log2(fold change) >1; Fig. 2d) and significantly elevated in the tumor tissues when compared with that in nontumor tissues in the Oncomine and GEO cohorts (Fig. 2e, f).