Notably, while loss of function in the FA pathway typically results in bone marrow failure and a cancer-prone phenotype (Nalepa and Clapp, 2018), these effects were not clearly manifested in Mettl14 RK mutant mice, suggesting that compensatory mechanisms might mitigate the impact of Mettl14 hypomethylation in these animals. Here, METTL14 is linked to cancer.