BRCA1 and Fanconi anemia: Consistent with our recent publication that METTL14 arginine methylation is important for cellular m6A homeostasis and the expression of genes involved in the Fanconi Anemia (FA) pathway (Wang et al, 2021), we observed a significant reduction of mRNA m6A (Appendix Fig. S5C) and the expression levels of several key genes in the FA pathway, including BRCA1, ATRIP, and PALB2, in thymus tissues from the METTL14 arginine methylation deficient RK mutant compared to their WT counterparts (Fig. 6C).