Interestingly, by using Gepia2 web server [9] we compared the expression levels of CASP8 and NFE2L2 genes in tumors and normal tissues from The Cancer Genome Atlas (TCGA) database; the expression of both genes is aberrantly upregulated in several cancers, including GBM (Supplementary Fig. S1B). The gene discussed is CASP8; the disease is cancer.