More recently, we and others showed that the aberrant activation of Src and the subsequent phosphorylation of Caspase-8 on Y380 drive also the acquisition by glioblastoma cells of new non canonical functions of Caspase-8 that overall, sustain tumorigenic progression and a poor prognosis [3–5, 7, 8]. Here, CASP8 is linked to glioblastoma.