In this regard, we and others demonstrated that the aberrant activity of Src tyrosine kinase, detected in several tumors, is responsible for Caspase-8 phosphorylation on Tyrosine 380 (Y380); this phosphorylation rewires Caspase-8 function dampening its canonical apoptotic activity [6, 7] and promoting its non-canonical pro-angiogenic and pro-inflammatory functions that overall sustain tumor progression and therapy resistance in GBM [3, 6, 8]. Here, CASP8 is linked to glioblastoma.