PRL and Headache: Headache is frequent in patients with hyperprolactinemia19, 30, 31, 32, 33, 34, 35, 36, 37, 38 and although factors such as increased intrasellar pressure and invasion of pain‐sensitive structures caused by the pituitary adenoma may contribute to headache, several lines of evidence suggest a direct role of prolactin in headache pathophysiology.