Recent studies identified >15 de novo mutations in the GNAI1 gene, which encodes the Gαi1 subunit of heterotrimeric G (αβγ) proteins, in individuals with a novel neurodevelopmental disorder (NDD) henceforth referred to as “GNAI1 disorder” (Muir et al. 2021). This evidence concerns the gene GNAI1 and Neurodevelopmental delay.