As shown in Supplementary Fig. S14, by regression analysis, the Trp53 to Apc flox site log2 CNR met these expectations across AK, AKPfl/fl, and AKPfl mice, supporting biallelic copy loss of both Apc (in AK and AKP) and Trp53 (in AKP) in these colorectal carcinoma tumor models. This evidence concerns the gene ADK and neoplasm.