MYC and colorectal carcinoma: Although no prioritized homozygous deletions were detected in any of the 242 evaluable tumor samples (outside of floxed targets used in model creation; see above), we observed a total of five high-level amplifications: a Myc amplification in a colorectal carcinoma GEMM, a Pik3ca amplification (log2 CNR of 2.7) in a colorectal carcinoma GEMM, and three HGSC with Myc amplifications (Fig. 4C–E; Supplementary Table S5).