As shown in Supplementary Fig. S14, by regression analysis, the Trp53 to Apc flox site log2 CNR met these expectations across AK, AKPfl/fl, and AKPfl mice, supporting biallelic copy loss of both Apc (in AK and AKP) and Trp53 (in AKP) in these colorectal carcinoma tumor models. The gene discussed is APC; the disease is colorectal carcinoma.