CDX2 and cancer: Interestingly, when comparing the dependency scores of these seven genes in colorectal carcinoma cell lines with those of 17 other cancer cell lines, only CDX2 was more significantly essential in colorectal carcinoma (q value <0.05), consistent with previous reports that CDX2 acts as a lineage-specific oncogene in the context of colorectal carcinoma cell lines (Supplementary Fig. S17B; ref. 120).