MYC and colorectal carcinoma: Of note, in the absence of clear driver genes also covered by MiMouse, we cannot definitively evaluate the scenario of sub-chromosomal gains in syntenic regions or single genes; however, outside of Myc, which had a low-level amplifications in eight of 28 colorectal carcinoma GEMM models (which is a candidate driver from the human 8q recurrent aneuploidy event), the lack of such events in human colorectal carcinoma and the overall fidelity of aneuploidy-based CN profile in the GEMM model make this scenario less important.