Highlighting the potential impact of synteny on localizing driver genes to these regions, at least three separate “peaks” have been reported in an ∼80 Mb region (from 13q12.2 to 13q33.3; ref. 46) in the colorectal carcinoma–specific 13q gain, with this region (and candidate driver genes; refs. 46–48, 120) mapping to mouse chr 14 (containing KLF5 and CUL4A), chr 8, chr 5 (containing CDX2 and CDK8), chr 3, and chr 1 (Fig. 6B). Here, CUL4A is linked to colorectal carcinoma.