APP and Alzheimer disease: Notably, gene encoded proteins like APP, MAPT, PSEN1, APOE ε4 allele, BACE1, and TREM2 are strongly associated with AD (H. Zhang et al. 2021a, b; Soler-López et al. 2011), and SNCA, PINK1, LRRK2, PARKN, PARK7, and MAOB, linked to PD (Va acute zquez-Ve acute lez and Zoghbi 2021).