APP and Alzheimer disease: KEGG pathway maps, specifically “pathways of neurodegeneration-multiple disease,” is the most enriched pathway with a large count of interacting partners shared by APP, MAPT, and SNCA interactors, in the etiology of diverse neuropathologies related to AD-PD seed proteins, and are correlated with current knowledge of the biological pathways implicated in NDD (Zhang et al. 2021b; Xu et al. 2023).