However, there is no previous report about the correlation between breast cancer subtype and sporadic somatic mutation of STK11. Genomic inactivation of STK11 has been linked to ICI resistance in metastatic breast cancer patients with all subtypes [24], and STK11 mutations have been detected in circulating tumor cells from all subtypes of breast cancer patients [25]. The gene discussed is STK11; the disease is breast carcinoma.