However, no prior studies have reported a correlation between breast cancer subtypes and sporadic somatic mutations in STK11. To explore this relationship, we utilized three murine breast cancer models to assess cellular responses following Stk11 suppression: PY8119 from TNBC, M158 from c-MYC-overexpressed, and NF639 from c-neu-overexpressed mammary gland tumor. Here, STK11 is linked to breast cancer.