The pattern of co-expression of TIM-3, LAG-3 and PD-1 observed in NK cells differs from that found in T cells (p < 0.0001) and NKT-like cells (p < 0.0001), in both healthy donors and AML patients whereas a similar pattern of co-expression was observed between T and NKT-like cells (Fig. 3 and supplementary Figure S2). This evidence concerns the gene PDCD1 and acute myeloid leukemia.