The aim of this work was to analyze the expression of LAG-3, TIM-3 and PD-1 on peripheral blood lymphocytes (NK cells, CD4 and CD8 T cells and CD3 + CD56 + NKT-like cells), in newly diagnosed AML patients compared to healthy donors and its possible relevance as biomarkers of patient survival. Here, LAG3 is linked to acute myeloid leukemia.