In AML patients, Kaplan–Meier survival analysis according to the co-expression patterns of LAG-3, TIM-3 and PD-1 showed that LAG-3+ TIM-3+ PD-1+ in NK, T and NKT-like cell subsets is higher in patients with lower survival although the differences were not statistically significant (Supplementary Figure S4). This evidence concerns the gene HAVCR2 and acute myeloid leukemia.