PSMD14 and neoplasm: Recent studies, however, have shown that lactate is abundantly produced during the Warburg effect in the tumor microenvironment and can trigger histone lysine lactylation, which is a new epigenetic modification that stimulates gene copying directly from chromatin.[18] To investigate whether PSMD14 influences lactate levels in PC cells and subsequently mediates histone lactylation, we first measured lactate levels in PSMD14‐overexpressing and PSMD14‐knockdown PC cells.