ACLY and familial pancreatic carcinoma: Additionally, lipids play an essential role in tumors, not only by acts as sources for biosynthetic precursors and energy but also by participating in signal transduction, membrane structure formation, and tumor microenvironment regulation.[7, 8] Our study demonstrated that transcriptional activation of ACLY directly enhances lipid synthesis in pancreatic cancer cells, a process closely linked to the malignant phenotype of pancreatic cancer and potentially explaining the poor prognosis observed in patients with high PSMD14 expression.