FBXO44 has been reported to act as a substrate adaptor in SCF E3 ligase complexes during the progression of various diseases.[14, 15, 16] Additionally, it has been shown to inhibit repetitive DNA elements in cancer cells through the recruitment of chromatin modifiers.[26] However, the function of FBXO44 in CRC is not fully understood. The gene discussed is KITLG; the disease is cancer.