Previous research indicates that APOE4‐expressing microglia display enhanced proinflammatory gene expression and impaired Aβ phagocytosis compared to APOE3 microglia, with reduced colocalization with amyloid plaque deposits.[66, 67] Additionally, higher SUA levels have been shown to benefit cognitive function in mild cognitive impairment (MCI) patients carrying the APOE4 allele.[68] These findings suggest that the effects of UA on microglial function may be influenced by APOE genotype. The gene discussed is APOE; the disease is Cognitive impairment.