Reduced expression of VPS35, a key component of the retromer, has been demonstrated in microglia from AD patients, exacerbating neuropathology in Cx3cr1‐Cre; VPS35;5×FAD mice.[69, 70] Therefore, UA may enhance the expression of recycling mediators, improving the dynamics and phagocytic ability of these receptors. The gene discussed is VPS35; the disease is Alzheimer disease.