To avoid hyperuricemia‐related complications, we administered UA at a dose of 200 mg kg−1 daily for two months, as previous described.[39] Our dosing regimen maintained mildly elevated ISF UA levels for ≈9 h without significant effects on neuroinflammation or renal function, differing from previous methods involving stereotactic injection or uricase (Uox)‐knockout strategies.[54, 55] These results suggest that our protocol is physiologically relevant and reliable for studying the effects of UA in mice despite interspecies differences in SUA levels. This evidence concerns the gene UOX and hyperuricemia.