ACHE and Alzheimer disease: These findings are consistent with previous studies reporting diminished SUA levels in AD patients and a protective effect of higher baseline SUA against incident dementia.[23, 25, 50, 51] Conversely, some studies have linked elevated SUA levels to heightened risk of vascular or mixed dementia and altered acetylcholinesterase activity,[52, 53] indicating that the relationship between UA levels and AD is complex and may involve multiple factors.