Partial inhibition of complex I can improve energy homeostasis, reduce oxidative stress and inflammation, and enhance cognitive function in models of Alzheimer's disease.[85] Collectively, our data presented in this study suggest that O‐Mit MDHB‐mediated targeting mitochondrial ND1 could be a promising strategy for promoting lung health and inhibition of the onset of inflammation‐related lung conditions thereby opening a new avenue for plant mitochondria transfer therapy. This evidence concerns the gene MT-ND1 and early-onset autosomal dominant Alzheimer disease.