This enzyme cleaves vitaminB9 (folic acid) and other glutamylated substrates to release freeglutamate, which in turn activates mGluR receptors on the tumor cells.mGluR activation triggers downstream pro-oncogenic signaling pathwayssuch as PI3K/AKT which promote cell survival while MAPK/ERK activationenhances growth and metastatic potential. PSMA modulates the tumor microenvironment by altering integrin signalingand facilitating vascular remodeling, thus feeding the tumor withmore nutrients and oxygen. The gene discussed is AKT1; the disease is neoplasm.