Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the pathological aggregation of misfolded proteins such as α‐synuclein.33 Preclinical evidence indicates that the glymphatic system may be impaired in PD.5,26–28 Zou et al34 showed that ligating the deep cLNs in A53T mice expressing mutant human α‐synuclein led to perivascular clustering of α‐synuclein and disrupted AQP4 polarization in the substantia nigra. This evidence concerns the gene AQP4 and Parkinson disease.