DDAH2 and bacterial infectious disease with sepsis: This may not only lead to the passivation of NO signals but also result in the subsequent impairment of pathogen defense, indicating that DDAH2 promotes the response to severe bacterial sepsis to a large extent by regulating the inflammatory response of macrophages (Lambden et al., 2015; Lambden et al., 2018; Winkler et al., 2017).