Similar to PD-1 KO mice (Figure 7F), isotype-treated Mφ-PD-L1 KO mice exhibited suppressed tumor growth compared to their Cd274fl/fl (WT) littermate controls, and both combination-treated Mφ-PD-L1 KO and WT mice had improved tumor control (Figure 7K). This evidence concerns the gene CD274 and neoplasm.