CDH2 and posterior cortical atrophy: Figure 2 shows the IHC staining from N-cadherin, β-catenin, and E-cadherin expression on the PCa TMAs (N = 403). The results showed that N-cadherin expression poses non-statistical differences when comparing its expression within different Gleason scores (Figure 2a). In addition, we found that β-catenin and E-cadherin expression reduces with increasing Gleason scores (Figure 2b,c), suggesting a potential cell-to-cell detachment, related to the development of aggressive PCa.