Recent findings suggest that CCR6-expressing CD4+ T cell subsets, including Th17, Th1Th17, and CCR6+CCR4-CXCR3- cells, represent a substantial and preferentially infected reservoir in the gut, enriched for replication-competent HIV due to their mucosal localization, memory phenotype, and high susceptibility to infection (47–49). Here, CCR6 is linked to infection.