Among the 17 candidate proteins, seven (Angiopoietin-1, BDNF, bFGF, MMP2, Neuropilin-1, EGF, and VEGFa) were significantly upregulated in the NPC-CM compared to the control medium (DMEM/F-12) (Figures 7A, B), suggesting a potential role of the NPC-derived secretome in promoting neurogenesis. This evidence concerns the gene EGF and nasopharyngeal carcinoma.