HNRNPU has been proven to be highly expressed in pancreatic cancer and is associated with poor prognosis (29–31).While K48-linked ubiquitination is the canonical signal for proteasomal degradation, other types of ubiquitination, such as K11-linked, have recently emerged as important regulators of protein stability and function. This evidence concerns the gene HNRNPU and familial pancreatic carcinoma.