Conversely, the circulating plasma levels of type 1 cytokines (IFN-γ, TNF-α, IL-2), and proinflammatory cytokines (IL-1α, and IL-1β) were significantly diminished in TB with CMV positive and CMV intermediate individuals compared to those without CMV (Table 5, Figure 1). The gene discussed is IL1A; the disease is tuberculosis.