Elevated TGM2 levels were associated with an immunosuppressive microenvironment: decreased Th1 (R = -0.186, P < 0.0001) and NK cell infiltration (R = -0.116, P = 0.0092), and increased M2 macrophage (R = 0.164–0.528, P < 0.0001) and cancer-associated fibroblast infiltration (R = 0.469, P < 0.0001). Here, TGM2 is linked to cancer.