TGM2 and cancer: TGM2-high tumors showed significant reductions in Th1 cells (P = 0.0048) and Th2 cells (P = 0.002), with concurrent increases in M2 macrophages (QUANTISEQ/XCELL, P < 0.0001), cancer-associated fibroblasts (P < 0.0001), hematopoietic stem cells (P < 0.0001), and endothelial cells (P < 0.0001) (Supplementary Figure S2).