SIRT1 and ovarian cancer: It has been found that TILs in ovarian cancer are often accompanied by mitochondrial dysfunction and aberrant upregulation of oxidative phosphorylation (OXPHOS), which in turn induces SIRT1 activation and accumulation of metabolic stresses.OXPHOS inhibitors and SIRT1 inhibitors can reverse TIL depletion by regulating cellular metabolic pathways.