It has been found that TILs in ovarian cancer are often accompanied by mitochondrial dysfunction and aberrant upregulation of oxidative phosphorylation (OXPHOS), which in turn induces SIRT1 activation and accumulation of metabolic stresses.OXPHOS inhibitors and SIRT1 inhibitors can reverse TIL depletion by regulating cellular metabolic pathways. The gene discussed is SIRT1; the disease is ovarian carcinoma.