HIF1A and hepatocellular carcinoma: Notch signaling exhibits tissue-specific regulatory patterns across different cancer types: in ovarian cancer, it promotes lipogenesis through activation of the SREBP-1/FASN axis (73), in triple-negative breast cancer, it impairs fatty acid oxidation via Hes1-mediated suppression of CPT1A expression (74), while in hepatocellular carcinoma, the HIF-1α-mediated inhibition of FAO can be reversed through combination targeted therapies (75).