In acute T-cell lymphoblastic leukemia (T-ALL), inhibiting the Notch1 signaling pathway influences glutamine catabolism (76).Activated Notch1 signaling influences the growth and metabolism of leukemia cells through the MYC protein (77).The MYC protein can upregulate the expression of branched-chain aminotransferase 1 (BCAT1), promoting the catabolism of branched-chain amino acids (BCAA) (78–80); and it can promote the translation of glutaminase 1 (GLS1) by inhibiting miR-23a/b, thereby increasing glutamine catabolism (81, 82). The gene discussed is NOTCH1; the disease is leukemia.