In contrast to the known role as a tumor suppressor in solid and hematologic cancers, our integrative analyses identified PTPRG among seven stemness‐related genes upregulated in MalPlasma3 and poor‐survival cells, which was echoed in the observed reduced cell viability and increased apoptosis in MM cell lines following siRNA‐mediated PTPRG knockdown. This evidence concerns the gene PTPRG and neoplasm.