In addition, adoptive transfer of macrophages engineered to overexpress Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) enhance the anti-inflammatory phenotype of kidney macrophages by PI3K/protein kinase B (AKT) pathway, resulting in reduced fibrosis and improved kidney function in CKD (140). The gene discussed is AKT1; the disease is chronic kidney disease.