INS and obesity due to melanocortin 4 receptor deficiency: The effect of obesity is also very often caused by disturbances in the intestinal microbiota, which plays a significant role in the modulation of the reproductive endocrine system through interactions with insulin, androgens, or estrogens - hormones crucial for the carcinogenesis of the female reproductive tract, which can also affect the composition of the microorganisms inhabiting the uterine cavity.