CD79A and hereditary clear cell renal cell carcinoma: Meylan et al, studied the response of B cells within TLS in renal cell carcinoma through spatial transcriptomics and found that IgG- and IgA-secreting plasma cells could move toward the tumor site along fibroblasts; and tumors positive for TLS had higher activity of IgG-secreting plasma cells and anti-tumor activity (28).