These proteins selected for their potential pathophysiological relevance to ME/CFS include α-adrenergic receptors (ADRA1B, ADRA1D, ADRA2C), the sodium/potassium/calcium exchanger 3 (SLC24A3), the nuclear serine/arginine repetitive matrix protein 3 (SRRM3), the mitochondrial phospholipase D family member 6 (PLD6) and the intracellular testis-specific Y-encoded-like protein 2 (TSPYL2) (Table 2). The gene discussed is PLD6; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.