The proteins identified here have known functions potentially relevant to central ME/CFS and PCS pathophysiology, including roles in autonomic regulation (ADRA), neuronal signaling (SRRM3), mitochondrial function and TGF-β signaling (TSPYL2), vascular tone and calcium signaling (SLC2A43), and endothelial integrity and angiogenesis (TSPYL5). The gene discussed is TSPYL2; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.