To investigate the potential of Phospho-Rb S249, N-cadherin, β-catenin, and E-cadherin as biomarkers for identifying aggressive PCa in Puerto Rican patients, we stratified the patients based on their Gleason score (N=23), a key factor in determining the prognosis of prostatic malignancies [31]. The gene discussed is RB1; the disease is posterior cortical atrophy.