Although it is associated with severe RA in South India,[20] recent research suggests that DRB1*14 and *15 may protect against RA in Northeast India.[21] However, these Indian studies did not distinguish between subtypes, highlighting the need for further research across diverse populations to clarify the specific roles of DRB1*14 and *15 subtypes in RA susceptibility. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.