HLA-DRB1*04:05:01, DRB1*10:01:01, DQB1*04:01:01, and DPB1*02:01:02 alleles have been identified as RA risk alleles in Chinese Han patients, with specific haplotypes like HLA-DRB1*04:05:01 ~ DQB1*04:01:01 also present.[8] Additionally, the HLA-DRB1*04 allele is associated with anti-citrullinated protein antibody (ACPA)-positive RA in Malaysian Chinese individuals.[9] These findings suggest that relying solely on data from one Han subgroup can significantly underestimate the genetic heterogeneity of RA risk factors. This evidence concerns the gene PRTN3 and rheumatoid arthritis.