SOCS1 and cancer: PLGA (OVA/SOCS1 siRNA) nanoparticles showed effective uptake by bone marrow-derived dendritic cells (BMDCs), and these nanoparticles knocked out SOCS1 in BMDCs, resulting in the release of pro-inflammatory cytokines including TNF and interleukin (IL-2), which indicated that the system might be an effective method for cancer immunotherapy based on BMDCs (Heo et al., 2014).