Beyond immune regulation, it also contributes to cardiovascular disease-related pathways by mediating the cleavage of epidermal growth factor receptor (EGFR) ligands, which are implicated in the pathogenesis of conditions such as coronary artery disease, aneurysm, heart failure, and hypertension (Chemaly et al., 2017; Lu et al., 2011; Takayanagi et al., 2016). Here, EGFR is linked to cardiovascular disorder.