The top ten targets included AKT1 (degree = 86), TP53 (degree = 81), TNF (degree = 77), HSP90AA1 (degree = 76), ALB (degree = 75), CTNNB1 (degree = 74), VEGFA (degree = 74), JUN (degree = 70), ESR1 (degree = 60), and SIRT1 (degree = 56), which may represent the core targets of KSG against AD. Here, ESR1 is linked to Alzheimer disease.