In comparison to the AD group, the p-AKT/AKT ratios in the DNZ group and KH group were increased (#p < 0.05), indicating that donepezil and high-dose KSG could effectively activate the PI3K-AKT pathway, and that the effect of high-dose KSG was comparable to that of donepezil. The gene discussed is AKT1; the disease is Alzheimer disease.