Quercetin increases GPX4 and GSH/GSSG ratios, inhibits ROS, lipid peroxides, and iron overload, and suppresses iron-induced cell death in hepatocytes and the liver, alleviating NAFLD (Jiang et al., 2022; Huang et al., 2023). The gene discussed is GPX4; the disease is metabolic dysfunction-associated steatotic liver disease.