Among 614 matched pairs of cases and controls, 321 pairs were derived from the NHS cohort (mean age at biomarker assessment, 70.3 years; 100% postmenopausal women, mean BMI, 24.3 kg/m2; 29% with history of osteoporosis; 16% with prior bisphosphonate use) and 293 from the HPFS cohort (mean age, 63.8 years; 100% men; mean BMI, 25.1 kg/m2; <1% with history of osteoporosis; 5.1% with prior bisphosphonate use; 292 pairs in the sclerostin analyses as 1 pair were excluded because of a missing value; Table 1). Here, SOST is linked to osteoporosis.