In this study, we found that bone-related biomarkers, including osteocalcin, CTX, sclerostin, and bicarbonate, did not associate with incident hip fracture outcomes over an average of more than a decade of follow-up in women in a hip fracture nested case-control study, although higher sclerostin levels, and to a lesser degree higher osteocalcin levels, associated with lower fracture risk in men. The gene discussed is SOST; the disease is hip fracture.