In this study, a history of perioperative blood transfusion, high levels of C-reactive protein (CRP), D-dimer concentrations >500 μg/L, a history of hypertension, age ≥60 years, and prolonged bed rest were identified by univariate and multivariate logistic regression analyses as independent risk factors for perioperative lower-extremity DVT in patients with spinal fractures. Here, CRP is linked to deep vein thrombosis.