In this study, variables showing statistical significance in univariate analyses, including age, length of surgery, bed rest cycle, history of hypertension and coronary heart disease, perioperative blood transfusion, postoperative drainage, intraoperative hypothermic events, hypoproteinemia status, D-dimer and C-reactive protein levels on the first postoperative day were entered into logistic multivariate regression models as covariates to identify the independent risk factors for lower extremity deep vein thrombosis (DVT) after spinal fracture. The gene discussed is CRP; the disease is deep vein thrombosis.