The results of the logistic regression analysis revealed that a history of perioperative blood transfusion, a high level of C-reactive protein (CRP), a D-dimer concentration >500 μg/L, a history of hypertension, an age ≥60 years old, and a prolonged bed rest period were independent risk factors for perioperative lower-extremity DVT in spine fracture patients. The gene discussed is CRP; the disease is hypertensive disorder.