SERPINC1 and blood coagulation disease: This might be associated with the liver’s role in synthesizing anticoagulant factors (such as antithrombin III) (41, 42), consistent with Tsai et al.’s findings that the De Ritis ratio (AST/ALT) correlates with trauma severity, indicating that liver function metrics may serve as biomarkers for coagulopathy risk in TBI patients (43).