Prior research demonstrated that numerous pathways, including the receptor tyrosine kinase (RTK) pathways, the phosphatidylinositol 3-kinase/protein kinase B (PKB), also known as AKT/mammalian target of rapamycin (PI3K/AKT/mTOR), the rat sarcoma virus/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (Ras/Raf/MAPK/ERK), the Janus kinase/signal transducer activator of transcription factor (JAK/STAT) and Wnt/β-catenin, are crucial in the advancement and propagation of HCC. Here, AKT1 is linked to hepatocellular carcinoma.